|
|
INTERPARE The Protein Interfaceome Database |
|
Introduction
InterPare is a database server for protein interaction interface information. It contains large-scale interface data of proteins whose 3D-structures are known. Protein interface information is derived from three different methods.
Background
Most proteins function by interacting with other molecules. Their interaction interfaces are highly conserved throughout evolution to avoid undesirable interactions that lead to fatal disorders in cells. Rational drug discovery includes a step for identifying interaction sites of lead compound to the target molecules using computers. Identifying and classifying protein interaction interfaces on a large scale can help researchers identify drug targets more efficiently.
Description
We introduce a large-scale protein domain interaction interface database called InterPare. InterPare uses three methods:
1) the Euclidean distance method for checking the distance among subunits in multidomain proteins,
2) Accessible Surface Area (ASA) for detecting the buried region of a protein that is detached from a solvent when forming multimers or complexes,
3) the Voronoi diagram, a computational geometry method, that uses a mathematical definition of interface regions. InterPare includes tools with different display modes for viewing protein interior, surface, and interaction interfaces.
|
